Version 5.4
Homo sapiens Gene: TIMELESS
Summary
InnateDB Gene IDBG-41018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMELESS
Gene Name timeless homolog (Drosophila)
Synonyms hTIM; TIM; TIM1
Species Homo sapiens
Ensembl Gene ENSG00000111602
Encoded Proteins
IDBP-41020
timeless homolog (Drosophila)
IDBP-595680
timeless homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56416373-56449403
Strand Reverse strand
Band q13.3
Transcripts
ENST00000229201 ENSP00000229201
ENST00000553532 ENSP00000450607
ENST00000557589
ENST00000553314
ENST00000555808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 21 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002009 morphogenesis of an epithelium
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007067 mitotic nuclear division
GO:0007623 circadian rhythm
GO:0009582 detection of abiotic stimulus
GO:0009628 response to abiotic stimulus
GO:0030324 lung development
GO:0042752 regulation of circadian rhythm
GO:0044770 cell cycle phase transition
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048754 branching morphogenesis of an epithelial tube
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039994
View Gene Order
ENSBTAG00000020459
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.118631
RefSeq NM_003920
HUGO
OMIM
CCDS CCDS8918
HPRD 04864
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca