Version 5.4
Mus musculus Gene: Il28ra
Summary
InnateDB Gene IDBG-197156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il28ra
Gene Name interleukin 28 receptor alpha
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000062157
Encoded Proteins
IDBP-197158
interleukin 28 receptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25431490
Il28ra (Ifnlr1), Stat1 and Irf3 are required for antibiotics to prevent persistent murine norovirus infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185436:
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:135686287-135708181
Strand Forward strand
Band D3
Transcripts
ENSMUST00000074408 ENSMUSP00000074009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0002385 mucosal immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0034342 response to type III interferon
GO:0045087 innate immune response (InnateDB)
GO:0050691 regulation of defense response to virus by host
GO:0051607 defense response to virus
Cellular Component
GO:0032002 interleukin-28 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185436
View Gene Order
ENSBTAG00000001101
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8CGK5
TrEMBL Q3URN4
UniProt Splice Variant
Entrez Gene 242700
UniGene Mm.259623
RefSeq NM_174851
OMIM
CCDS CCDS18788
HPRD
IMGT
MGI ID MGI:2429859
MGI Symbol Ifnlr1
EMBL AK141338 AY184376 BC057856
GenPept AAH57856 AAN86129 BAE24654
RNA Seq Atlas 242700

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca