Version 5.4
Mus musculus Gene: Fam38a
Summary
InnateDB Gene IDBG-197463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam38a
Gene Name family with sequence similarity 38, member A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000014444
Encoded Proteins
IDBP-197467
family with sequence similarity 38, member A
IDBP-541810
family with sequence similarity 38, member A
IDBP-540840
family with sequence similarity 38, member A
IDBP-538511
family with sequence similarity 38, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103335:
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. \'Piezo\' comes from the Greek \'piesi,\' meaning \'pressure.\' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:122481698-122551329
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000067252 ENSMUSP00000089777
ENSMUST00000156333 ENSMUSP00000114584
ENSMUST00000123671
ENSMUST00000128383 ENSMUSP00000116194
ENSMUST00000134304
ENSMUST00000155803
ENSMUST00000126553
ENSMUST00000152596
ENSMUST00000148497 ENSMUSP00000121725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0008381 mechanically-gated ion channel activity
Biological Process
GO:0006812 cation transport
GO:0033625 positive regulation of integrin activation
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050982 detection of mechanical stimulus
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000103335
View Gene Order
Cross-References
SwissProt
TrEMBL F6QY99
UniProt Splice Variant
Entrez Gene 234839
UniGene Mm.490358
RefSeq NM_001037298 XM_006530953 XM_006530954 XM_006530955 XM_006530958 XM_006530959
OMIM
CCDS CCDS52695
HPRD
IMGT
MGI ID MGI:3603204
MGI Symbol Piezo1
EMBL AC114917
GenPept
RNA Seq Atlas 234839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca