Version 5.4
Homo sapiens Gene: PIEZO1
Summary
InnateDB Gene IDBG-46558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIEZO1
Gene Name piezo-type mechanosensitive ion channel component 1
Synonyms DHS; FAM38A; Mib
Species Homo sapiens
Ensembl Gene ENSG00000103335
Encoded Proteins
IDBP-46560
piezo-type mechanosensitive ion channel component 1
IDBP-46562
piezo-type mechanosensitive ion channel component 1
IDBP-381754
piezo-type mechanosensitive ion channel component 1
IDBP-754320
IDBP-751382
IDBP-474247
piezo-type mechanosensitive ion channel component 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. \'Piezo\' comes from the Greek \'piesi,\' meaning \'pressure.\' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:88715343-88785211
Strand Reverse strand
Band q24.3
Transcripts
ENST00000327397 ENSP00000333704
ENST00000301015 ENSP00000301015
ENST00000419505 ENSP00000406358
ENST00000518793 ENSP00000456680
ENST00000484567
ENST00000521877
ENST00000472168
ENST00000495568
ENST00000466823 ENSP00000456373
ENST00000497793
ENST00000474606 ENSP00000428673
ENST00000475586
ENST00000491917
ENST00000490756
ENST00000566414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0008381 mechanically-gated ion channel activity
Biological Process
GO:0006812 cation transport
GO:0033625 positive regulation of integrin activation
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050982 detection of mechanical stimulus
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000014444
View Gene Order
Cross-References
SwissProt
TrEMBL E7EUT2
UniProt Splice Variant
Entrez Gene 9780
UniGene Hs.377001
RefSeq NM_001142864 XM_006721353
HUGO HGNC:28993
OMIM 611184
CCDS CCDS54058
HPRD 10945
IMGT
EMBL AC092384 AC138028
GenPept
RNA Seq Atlas 9780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca