InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gale

Summary

InnateDB Gene

IDBG-197476.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gale

Gene Name

galactose-4-epimerase, UDP

Synonyms

2310002A12Rik; AI323962

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028671

Encoded Proteins

IDBP-197478

galactose-4-epimerase, UDP

IDBP-197482

galactose-4-epimerase, UDP

IDBP-537821

galactose-4-epimerase, UDP

IDBP-540869

galactose-4-epimerase, UDP

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117308:
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (\'peripheral\' form) to severe (\'generalized\' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:135963727-135968178

Strand

Forward strand

Band

Transcripts

ENSMUST00000102541	ENSMUSP00000099600
ENSMUST00000102540	ENSMUSP00000099599
ENSMUST00000149636	ENSMUSP00000117923
ENSMUST00000128929
ENSMUST00000143304	ENSMUSP00000119514
ENSMUST00000153542
ENSMUST00000150430

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003978	UDP-glucose 4-epimerase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0050662	coenzyme binding

Biological Process

GO:0006012	galactose metabolic process
GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0019388	galactose catabolic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process