InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gale

Summary

InnateDB Protein

IDBP-197482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gale

Protein Name

galactose-4-epimerase, UDP

Synonyms

2310002A12Rik; AI323962;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099599

InnateDB Gene

IDBG-197476 (Gale)

Protein Structure

UniProt Annotation

Function

Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003978	UDP-glucose 4-epimerase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0050662	coenzyme binding

Biological Process

GO:0006012	galactose metabolic process
GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0019388	galactose catabolic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005575	cellular_component
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1921496

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005886 UDP-glucose 4-epimerase GalE
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR008089 Nucleotide sugar epimerase
IPR013120 Male sterility, NAD-binding
IPR013968 Polyketide synthase, KR

PFAM