Version 5.4
Mus musculus Gene: Bcat1
Summary
InnateDB Gene IDBG-197501.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcat1
Gene Name branched chain aminotransferase 1, cytosolic
Synonyms BCATc; Eca39
Species Mus musculus
Ensembl Gene ENSMUSG00000030268
Encoded Proteins
IDBP-164502
branched chain aminotransferase 1, cytosolic
IDBP-197505
branched chain aminotransferase 1, cytosolic
IDBP-257480
branched chain aminotransferase 1, cytosolic
IDBP-540530
branched chain aminotransferase 1, cytosolic
IDBP-540256
branched chain aminotransferase 1, cytosolic
IDBP-534632
branched chain aminotransferase 1, cytosolic
IDBP-538302
branched chain aminotransferase 1, cytosolic
IDBP-542654
branched chain aminotransferase 1, cytosolic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000060982:
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:144993835-145076184
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000048252 ENSMUSP00000039744
ENSMUST00000032402 ENSMUSP00000032402
ENSMUST00000111742 ENSMUSP00000107371
ENSMUST00000145911
ENSMUST00000136819 ENSMUSP00000117708
ENSMUST00000123930 ENSMUSP00000120180
ENSMUST00000155693 ENSMUSP00000116565
ENSMUST00000149769 ENSMUSP00000116091
ENSMUST00000154611 ENSMUSP00000123137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0042802 identical protein binding
GO:0052654 L-leucine transaminase activity
GO:0052655 L-valine transaminase activity
GO:0052656 L-isoleucine transaminase activity
Biological Process
GO:0008152 metabolic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009083 branched-chain amino acid catabolic process
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0034644 cellular response to UV
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000060982
View Gene Order
ENSBTAG00000013825
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_254568
Branched-chain amino acid catabolism pathway
KEGG
mmu00290
Valine, leucine and isoleucine biosynthesis pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00770
Pantothenate and CoA biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_197
Branched-chain amino acid catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00290
Valine, leucine and isoleucine biosynthesis pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00770
Pantothenate and CoA biosynthesis pathway
INOH
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL B2KFA6 B2KFA7
UniProt Splice Variant
Entrez Gene 12035
UniGene Mm.385258 Mm.4606
RefSeq NM_001024468 NM_007532 XM_006506912 XM_006536023
OMIM
CCDS CCDS20691 CCDS39703
HPRD
IMGT
MGI ID MGI:104861
MGI Symbol Bcat1
EMBL AC121950 AC140416
GenPept
RNA Seq Atlas 12035

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca