InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcat1

Summary

InnateDB Protein

IDBP-257480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcat1

Protein Name

branched chain aminotransferase 1, cytosolic

Synonyms

BCATc; Eca39;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107371

InnateDB Gene

IDBG-197501 (Bcat1)

Protein Structure

UniProt Annotation

Function

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in brain and kidney. Overexpressed in MYC-induced brain tumors, lymphomas, as well as in a teratocarcinoma cell line.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004084	branched-chain-amino-acid transaminase activity
GO:0042802	identical protein binding
GO:0052654	L-leucine transaminase activity
GO:0052655	L-valine transaminase activity
GO:0052656	L-isoleucine transaminase activity

Biological Process

GO:0008152	metabolic process
GO:0009081	branched-chain amino acid metabolic process
GO:0009082	branched-chain amino acid biosynthetic process
GO:0009083	branched-chain amino acid catabolic process
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0034644	cellular response to UV