InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf41

Summary

InnateDB Gene

IDBG-197506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf41

Gene Name

ring finger protein 41

Synonyms

2210404G21Rik; 4930511A05Rik; 4933415P08Rik; D10Ertd722e; FLRF; Nrdp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025373

Encoded Proteins

IDBP-271309

ring finger protein 41

IDBP-620645

ring finger protein 41

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19483718

[Homo sapiens] RNF41 is an E3 ligase that can negatively regulate MyD88-dependent production of pro-inflammatory cytokines but can promote TRIF-dependent production of type I interferon.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181852:
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128411616-128441438

Strand

Forward strand

Band

Transcripts

ENSMUST00000096386	ENSMUSP00000100869
ENSMUST00000171342	ENSMUSP00000132751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005128	erythropoietin receptor binding
GO:0005135	interleukin-3 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0031386	protein tag
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0016567	protein ubiquitination
GO:0030336	negative regulation of cell migration
GO:0043408	regulation of MAPK cascade
GO:0045619	regulation of lymphocyte differentiation
GO:0045637	regulation of myeloid cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865	protein autoubiquitination
GO:0051896	regulation of protein kinase B signaling
GO:0097191	extrinsic apoptotic signaling pathway
GO:2000114	regulation of establishment of cell polarity
GO:2000377	regulation of reactive oxygen species metabolic process