InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf41

Summary

InnateDB Protein

IDBP-271309.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf41

Protein Name

ring finger protein 41

Synonyms

2210404G21Rik; 4930511A05Rik; 4933415P08Rik; D10Ertd722e; FLRF; Nrdp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100869

InnateDB Gene

IDBG-197506 (Rnf41)

Protein Structure

UniProt Annotation

Function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, FLRF is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. {ECO:0000250, ECO:0000269PubMed:18495327, ECO:0000269PubMed:19483718}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005128	erythropoietin receptor binding
GO:0005135	interleukin-3 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0031386	protein tag
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0016567	protein ubiquitination
GO:0030336	negative regulation of cell migration
GO:0043408	regulation of MAPK cascade
GO:0045619	regulation of lymphocyte differentiation
GO:0045637	regulation of myeloid cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865	protein autoubiquitination
GO:0051896	regulation of protein kinase B signaling
GO:0097191	extrinsic apoptotic signaling pathway
GO:2000114	regulation of establishment of cell polarity
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005575	cellular_component

Protein Structure and Domains

PDB ID

MGI:1914838

InterPro

IPR001841 Zinc finger, RING-type
IPR003613 U box domain
IPR008974 TRAF-like
IPR013010 Zinc finger, SIAH-type
IPR015036 USP8 interacting
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF04564
PF08941
PF00097

PRINTS

PIRSF

SMART

SM00184
SM00504

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BH75