Mus musculus Gene: Cdt1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-197656.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Cdt1 | ||||||||||||||||||||||
Gene Name | chromatin licensing and DNA replication factor 1 | ||||||||||||||||||||||
Synonyms | 2610318F11Rik; AW545653; C76791; Ris2 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000006585 | ||||||||||||||||||||||
Encoded Proteins |
chromatin licensing and DNA replication factor 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167513:
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 8:122568015-122573128 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | E1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
CDT1 association with the CDC6:ORC:origin complex pathway
DNA Replication pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Association of licensing factors with the pre-replicative complex pathway
Switching of origins to a post-replicative state pathway
Activation of the pre-replicative complex pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the pre-replicative complex pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Regulation of DNA replication pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8R4E9 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 67177 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_026014 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS22741 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1914427 | ||||||||||||||||||||||
MGI Symbol | Cdt1 | ||||||||||||||||||||||
EMBL | AB086655 AF477481 AF477990 AK028287 AK049163 AK083015 BC024485 BC048076 | ||||||||||||||||||||||
GenPept | AAH24485 AAH48076 AAL82630 AAL88446 BAC22085 BAC25859 BAC33579 BAC38731 | ||||||||||||||||||||||
RNA Seq Atlas | 67177 | ||||||||||||||||||||||