Version 5.4
Mus musculus Gene: Cdt1
Summary
InnateDB Gene IDBG-197656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdt1
Gene Name chromatin licensing and DNA replication factor 1
Synonyms 2610318F11Rik; AW545653; C76791; Ris2
Species Mus musculus
Ensembl Gene ENSMUSG00000006585
Encoded Proteins
IDBP-197658
chromatin licensing and DNA replication factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167513:
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:122568015-122573128
Strand Forward strand
Band E1
Transcripts
ENSMUST00000006760 ENSMUSP00000006760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000076 DNA replication checkpoint
GO:0006260 DNA replication
GO:0030174 regulation of DNA-dependent DNA replication initiation
GO:0033262 regulation of nuclear cell cycle DNA replication
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167513
View Gene Order
ENSBTAG00000000638
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_244558
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188804
Cell Cycle pathway
REACT_255479
Regulation of DNA replication pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_245528
M/G1 Transition pathway
REACT_262002
Association of licensing factors with the pre-replicative complex pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
REACT_253623
S Phase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8R4E9
TrEMBL
UniProt Splice Variant
Entrez Gene 67177
UniGene
RefSeq NM_026014
OMIM
CCDS CCDS22741
HPRD
IMGT
MGI ID MGI:1914427
MGI Symbol Cdt1
EMBL AB086655 AF477481 AF477990 AK028287 AK049163 AK083015 BC024485 BC048076
GenPept AAH24485 AAH48076 AAL82630 AAL88446 BAC22085 BAC25859 BAC33579 BAC38731
RNA Seq Atlas 67177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca