InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdt1

Summary

InnateDB Protein

IDBP-197658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdt1

Protein Name

chromatin licensing and DNA replication factor 1

Synonyms

2610318F11Rik; AW545653; C76791; Ris2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006760

InnateDB Gene

IDBG-197656 (Cdt1)

Protein Structure

UniProt Annotation

Function

Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene. {ECO:0000269PubMed:11850834, ECO:0000269PubMed:12192004, ECO:0000269PubMed:14993212}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14993212}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0006260	DNA replication
GO:0030174	regulation of DNA-dependent DNA replication initiation
GO:0033262	regulation of nuclear cell cycle DNA replication