Version 5.4
Mus musculus Gene: Srd5a2
Summary
InnateDB Gene IDBG-197662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srd5a2
Gene Name steroid 5 alpha-reductase 2
Synonyms 5ART2; S5AR 2
Species Mus musculus
Ensembl Gene ENSMUSG00000038541
Encoded Proteins
IDBP-197664
steroid 5 alpha-reductase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74017706-74047916
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000043458 ENSMUSP00000048862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0033218 amide binding
GO:0047751 cholestenone 5-alpha-reductase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006706 steroid catabolic process
GO:0008202 steroid metabolic process
GO:0008209 androgen metabolic process
GO:0008584 male gonad development
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0018879 biphenyl metabolic process
GO:0018894 dibenzo-p-dioxin metabolic process
GO:0018963 phthalate metabolic process
GO:0021766 hippocampus development
GO:0021854 hypothalamus development
GO:0030154 cell differentiation
GO:0030539 male genitalia development
GO:0030540 female genitalia development
GO:0031667 response to nutrient levels
GO:0032354 response to follicle-stimulating hormone
GO:0033574 response to testosterone
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0048545 response to steroid hormone
GO:0055114 oxidation-reduction process
GO:0060348 bone development
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
GO:0070852 cell body fiber
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu05215
Prostate cancer pathway
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q99N99
TrEMBL Q99NA0
UniProt Splice Variant
Entrez Gene 94224
UniGene Mm.38933
RefSeq NM_053188
OMIM
CCDS CCDS28968
HPRD
IMGT
MGI ID MGI:2150380
MGI Symbol Srd5a2
EMBL AB049455 AB049456 AK138946 BC125510
GenPept AAI25511 BAB40178 BAB40179 BAE23830
RNA Seq Atlas 94224

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca