InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srd5a2

Summary

InnateDB Protein

IDBP-197664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srd5a2

Protein Name

steroid 5 alpha-reductase 2

Synonyms

5ART2; S5AR 2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048862

InnateDB Gene

IDBG-197662 (Srd5a2)

Protein Structure

UniProt Annotation

Function

Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). {ECO:0000250}.

Subcellular Localization

Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0033218	amide binding
GO:0047751	cholestenone 5-alpha-reductase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006702	androgen biosynthetic process
GO:0006706	steroid catabolic process
GO:0008202	steroid metabolic process
GO:0008209	androgen metabolic process
GO:0008584	male gonad development
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0018879	biphenyl metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0018963	phthalate metabolic process
GO:0021766	hippocampus development
GO:0021854	hypothalamus development
GO:0030154	cell differentiation
GO:0030539	male genitalia development
GO:0030540	female genitalia development
GO:0031667	response to nutrient levels
GO:0032354	response to follicle-stimulating hormone
GO:0033574	response to testosterone
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process
GO:0060348	bone development

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0070852	cell body fiber