Mus musculus Gene: Asap3
Summary
InnateDB Gene IDBG-197744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asap3
Gene Name ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036995
Encoded Proteins
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088280:
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:136206365-136245216
Strand Forward strand
Band D3
Transcripts
ENSMUST00000047526 ENSMUSP00000041899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0016477 cell migration
GO:0032312 regulation of ARF GTPase activity
GO:0032850 positive regulation of ARF GTPase activity
GO:0051492 regulation of stress fiber assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Fc gamma R-mediated phagocytosis pathway
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
KEGG
Fc gamma R-mediated phagocytosis pathway
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q5U464
TrEMBL
UniProt Splice Variant
Entrez Gene 230837
UniGene Mm.77788
RefSeq NM_001008232 XM_006538761 XM_006538762
OMIM
CCDS CCDS18802
HPRD
IMGT
MGI ID MGI:2684986
MGI Symbol Asap3
EMBL BC085250
GenPept AAH85250
RNA Seq Atlas 230837