Homo sapiens Gene: ASAP3
Summary
InnateDB Gene IDBG-93928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASAP3
Gene Name ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088280
Encoded Proteins
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:23428563-23484568
Strand Reverse strand
Band p36.12
Transcripts
ENST00000336689 ENSP00000338769
ENST00000449467
ENST00000437606 ENSP00000408826
ENST00000492982 ENSP00000435858
ENST00000495646 ENSP00000436150
ENST00000465372 ENSP00000435394
ENST00000484418 ENSP00000434897
ENST00000475814 ENSP00000436439
ENST00000478858
ENST00000530874
ENST00000608765 ENSP00000476400
ENST00000618240 ENSP00000483740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0016477 cell migration
GO:0032312 regulation of ARF GTPase activity
GO:0032850 positive regulation of ARF GTPase activity
GO:0051492 regulation of stress fiber assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
Fc gamma R-mediated phagocytosis pathway
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q8TDY4
TrEMBL
UniProt Splice Variant
Entrez Gene 55616
UniGene Hs.437379 Hs.595123
RefSeq NM_001143778 NM_017707 XM_005245934
HUGO HGNC:14987
OMIM
CCDS CCDS235 CCDS44087
HPRD 11662
IMGT
EMBL AB056749 AK000206 AK092291 AK295100 AL021154 AL357134 BC052305 BC060786 CH471134
GenPept AAH52305 AAH60786 BAA91008 BAB85677 BAG52522 BAG58136 CAI19596 CAI22177 EAW95050
RNA Seq Atlas 55616