InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Erbb3

Summary

InnateDB Gene

IDBG-197943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erbb3

Gene Name

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Synonyms

C76256; Erbb-3; Erbb3r; Her3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018166

Encoded Proteins

IDBP-197945

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065361:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128567523-128589652

Strand

Reverse strand

Band

Transcripts

ENSMUST00000082059

ENSMUSP00000080716

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0030296	protein tyrosine kinase activator activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0003197	endocardial cushion development
GO:0006468	protein phosphorylation
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422	peripheral nervous system development
GO:0009968	negative regulation of signal transduction
GO:0014037	Schwann cell differentiation
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021545	cranial nerve development
GO:0023014	signal transduction by phosphorylation
GO:0042127	regulation of cell proliferation
GO:0043524	negative regulation of neuron apoptotic process
GO:0051048	negative regulation of secretion
GO:0051402	neuron apoptotic process
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0043235	receptor complex