InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trpv1

Summary

InnateDB Gene

IDBG-198046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv1

Gene Name

transient receptor potential cation channel, subfamily V, member 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005952

Encoded Proteins

IDBP-198048

transient receptor potential cation channel, subfamily V, member 1

IDBP-198050

transient receptor potential cation channel, subfamily V, member 1

IDBP-264469

transient receptor potential cation channel, subfamily V, member 1

IDBP-541120

transient receptor potential cation channel, subfamily V, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000262304:
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008] Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5\' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:73234292-73261242

Strand

Forward strand

Band

Transcripts

ENSMUST00000102526	ENSMUSP00000099585
ENSMUST00000006106	ENSMUSP00000006106
ENSMUST00000108470	ENSMUSP00000104110
ENSMUST00000138853	ENSMUSP00000116400
ENSMUST00000128113

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004698	calcium-dependent protein kinase C activity
GO:0004888	transmembrane signaling receptor activity
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005231	excitatory extracellular ligand-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008324	cation transmembrane transporter activity
GO:0015276	ligand-gated ion channel activity
GO:0015278	calcium-release channel activity
GO:0017081	chloride channel regulator activity
GO:0042802	identical protein binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001660	fever generation
GO:0001774	microglial cell activation
GO:0002024	diet induced thermogenesis
GO:0002790	peptide secretion
GO:0006468	protein phosphorylation
GO:0006629	lipid metabolic process
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009268	response to pH
GO:0009408	response to heat
GO:0010243	response to organonitrogen compound
GO:0014047	glutamate secretion
GO:0014832	urinary bladder smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0034220	ion transmembrane transport
GO:0042637	catagen
GO:0043065	positive regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0050954	sensory perception of mechanical stimulus
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0060083	smooth muscle contraction involved in micturition
GO:0060454	positive regulation of gastric acid secretion
GO:0070588	calcium ion transmembrane transport
GO:0071312	cellular response to alkaloid
GO:0071318	cellular response to ATP
GO:0071345	cellular response to cytokine stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071502	cellular response to temperature stimulus
GO:0090212	negative regulation of establishment of blood-brain barrier
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0031226	intrinsic component of plasma membrane
GO:0032591	dendritic spine membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Bos taurus

Homo sapiens

Gene ID

Gene Order

ENSBTAG00000018880

Not yet available

ENSG00000262304

View Gene Order

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_227861

TRP channels pathway

KEGG

mmu04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.447485

RefSeq

NM_001001445 XM_006532580 XM_006532581 XM_006536293 XM_006536294

OMIM

CCDS

CCDS25003

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas