InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SHPK

Summary

InnateDB Gene

IDBG-727056.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHPK

Gene Name

transient receptor potential cation channel subfamily V member 1

Synonyms

CARKL; SHK; VR1

Species

Homo sapiens

Ensembl Gene

ENSG00000262304

Encoded Proteins

IDBP-761191

IDBP-759506

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008] Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5\' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:3565444-3636249

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000572705	ENSP00000459962
ENST00000572919	ENSP00000461416

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005216	ion channel activity
GO:0005231	excitatory extracellular ligand-gated ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0015278	calcium-release channel activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0051219	phosphoprotein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0007166	cell surface receptor signaling pathway
GO:0007635	chemosensory behavior
GO:0034220	ion transmembrane transport
GO:0050955	thermoception
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071312	cellular response to alkaloid
GO:0071318	cellular response to ATP

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031226	intrinsic component of plasma membrane
GO:0032591	dendritic spine membrane
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005952

View Gene Order

ENSBTAG00000018880

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_080704

HUGO

OMIM

CCDS

CCDS11030 CCDS45576

HPRD

03648

IMGT

EMBL

GenPept

RNA Seq Atlas