Version 5.4
Mus musculus Gene: Vps29
Summary
InnateDB Gene IDBG-198096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps29
Gene Name vacuolar protein sorting 29 (S. pombe)
Synonyms 2010015D08Rik; AW049835; PEP11
Species Mus musculus
Ensembl Gene ENSMUSG00000029462
Encoded Proteins
IDBP-257512
vacuolar protein sorting 29 (S. pombe)
IDBP-400278
vacuolar protein sorting 29 (S. pombe)
IDBP-400281
vacuolar protein sorting 29 (S. pombe)
IDBP-400280
vacuolar protein sorting 29 (S. pombe)
IDBP-538307
vacuolar protein sorting 29 (S. pombe)
IDBP-534190
vacuolar protein sorting 29 (S. pombe)
IDBP-535697
vacuolar protein sorting 29 (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111237:
This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:122354369-122364984
Strand Forward strand
Band F
Transcripts
ENSMUST00000111729 ENSMUSP00000107358
ENSMUST00000118830 ENSMUSP00000113525
ENSMUST00000118765 ENSMUSP00000112579
ENSMUST00000117868 ENSMUSP00000113345
ENSMUST00000155671 ENSMUSP00000121020
ENSMUST00000132785
ENSMUST00000145821 ENSMUSP00000123593
ENSMUST00000154686 ENSMUSP00000118991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004647 phosphoserine phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006896 Golgi to vacuole transport
GO:0015031 protein transport
GO:0016311 dephosphorylation
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0030904 retromer complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111237
View Gene Order
ENSBTAG00000008417
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_213918
WNT ligand biogenesis and trafficking pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_246422
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_228014
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_111102
Signal Transduction pathway
REACT_163710
WNT ligand biogenesis and trafficking pathway
REACT_116125
Disease pathway
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_209527
WNT ligand biogenesis and trafficking pathway
REACT_240074
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_214353
Signal Transduction pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.392651
RefSeq NM_019780 XM_006530427
OMIM
CCDS CCDS39256
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca