InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vps29

Summary

InnateDB Protein

IDBP-400278.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps29

Protein Name

vacuolar protein sorting 29 (S. pombe)

Synonyms

2010015D08Rik; AW049835; PEP11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113525

InnateDB Gene

IDBG-198096 (Vps29)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p- nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000269PubMed:15965486}; Peripheral membrane protein {ECO:0000269PubMed:15965486}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004647	phosphoserine phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006896	Golgi to vacuole transport
GO:0015031	protein transport
GO:0016311	dephosphorylation

Cellular Component

GO:0010008

endosome membrane

Protein Structure and Domains

PDB ID

MGI:1928344

InterPro

IPR000979 Phosphodiesterase MJ0936/Vps29
IPR029052 Metallo-dependent phosphatase-like

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZ88

PhosphoSite

PhosphoSite-Q9QZ88

TrEMBL

UniProt Splice Variant

Entrez Gene

56433

UniGene

Mm.392651

RefSeq

XP_006530490

MGI ID

3PSO

MGI Symbol

Vps29

OMIM

CCDS

HPRD

IMGT

EMBL

AF193794 AK004103 AK150330 BC005663

GenPept

AAF04595 AAH05663 BAB23170 BAE29472