InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tyr

Summary

InnateDB Gene

IDBG-198127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyr

Gene Name

tyrosinase

Synonyms

albino; c; Oca1; skc35

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004651

Encoded Proteins

IDBP-198129

tyrosinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077498:
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3\' half of this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:87427405-87493411

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004770

ENSMUSP00000004770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004503	monophenol monooxygenase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0048538	thymus development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000077498

View Gene Order

ENSBTAG00000011813

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00350

Tyrosine metabolism pathway

mmu04916

Melanogenesis pathway

mmu00740

Riboflavin metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00740

Riboflavin metabolism pathway

hsa00350

Tyrosine metabolism pathway

hsa04916

Melanogenesis pathway

INOH

INOH website

Tyrosine metabolism pathway

PID NCI

Cross-References

SwissProt

P11344

TrEMBL

Q91XK0

UniProt Splice Variant

Entrez Gene

22173

UniGene

Mm.238127

RefSeq

NM_011661

OMIM

CCDS

CCDS52304

HPRD

IMGT

MGI ID

MGI:98880

MGI Symbol

Tyr

EMBL

AK014619 BC079678 CH466543 D00131 D00439 D00440 M20234 M24560 M26729 X12782 X51743

GenPept

AAA37806 AAA40516 AAA40517 AAH79678 BAA00079 BAA00340 BAA00341 BAB29466 CAA31273 CAA36033 EDL06801

RNA Seq Atlas

22173