InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tyr

Summary

InnateDB Protein

IDBP-198129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyr

Protein Name

tyrosinase

Synonyms

albino; c; Oca1; skc35;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004770

InnateDB Gene

IDBG-198127 (Tyr)

Protein Structure

UniProt Annotation

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

Subcellular Localization

Melanosome membrane; Single-pass type I membrane protein.

Disease Associations

Note=Defects in Tyr result in various forms of albinism. Himalayan strain tyrosinase is temperature-sensitive.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004503	monophenol monooxygenase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0048538	thymus development
GO:0055114	oxidation-reduction process