Version 5.4
Mus musculus Gene: Sema3f
Summary
InnateDB Gene IDBG-198155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sema3f
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms Sema4; Semak
Species Mus musculus
Ensembl Gene ENSMUSG00000034684
Encoded Proteins
IDBP-198157
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001617:
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:107681502-107710475
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000080560 ENSMUSP00000079400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0045499 chemorepellent activity
Biological Process
GO:0001755 neural crest cell migration
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0021612 facial nerve structural organization
GO:0021637 trigeminal nerve structural organization
GO:0021675 nerve development
GO:0021785 branchiomotor neuron axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0050919 negative chemotaxis
GO:0061549 sympathetic ganglion development
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000001617
View Gene Order
ENSBTAG00000018307
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt O88632
TrEMBL
UniProt Splice Variant
Entrez Gene 20350
UniGene Mm.12903
RefSeq NM_011349 XM_006511676
OMIM
CCDS CCDS23505
HPRD
IMGT
MGI ID MGI:1096347
MGI Symbol Sema3f
EMBL AC152718 AC162905 AF080090 AF080091 BC010976
GenPept AAC28108 AAC28109 AAH10976
RNA Seq Atlas 20350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca