InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SEMA3F

Summary

InnateDB Gene

IDBG-645842.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA3F

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018307

Encoded Proteins

IDBP-698610

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001617:
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:50733157-50756457

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024362

ENSBTAP00000024362

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0045499	chemorepellent activity

Biological Process

GO:0001755	neural crest cell migration
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0021612	facial nerve structural organization
GO:0021637	trigeminal nerve structural organization
GO:0021675	nerve development
GO:0021785	branchiomotor neuron axon guidance
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance

Cellular Component

GO:0016020

membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000001617

View Gene Order

ENSMUSG00000034684

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04360

Axon guidance pathway

mmu04360

Axon guidance pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MGN0

UniProt Splice Variant

Entrez Gene

531141

UniGene

RefSeq

XM_002697033 XM_609627

HUGO

HGNC:10728

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02054414

GenPept

RNA Seq Atlas

531141