Version 5.4
Mus musculus Gene: Arpc3
Summary
InnateDB Gene IDBG-198169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc3
Gene Name actin related protein 2/3 complex, subunit 3
Synonyms 1110006A04Rik; 21kDa; AA408672; AI788639; p21-Ar; p21Arc
Species Mus musculus
Ensembl Gene ENSMUSG00000029465
Encoded Proteins
IDBP-198171
actin related protein 2/3 complex, subunit 3
IDBP-198173
actin related protein 2/3 complex, subunit 3
IDBP-257540
actin related protein 2/3 complex, subunit 3
IDBP-257542
actin related protein 2/3 complex, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111229:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined. [provided by RefSeq, Jul 2008]
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:122391878-122406179
Strand Forward strand
Band F
Transcripts
ENSMUST00000102525 ENSMUSP00000099584
ENSMUST00000031421 ENSMUSP00000031421
ENSMUST00000111716 ENSMUSP00000107345
ENSMUST00000111713 ENSMUSP00000107342
ENSMUST00000148913
ENSMUST00000141395
ENSMUST00000126247
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0030833 regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111229
View Gene Order
ENSBTAG00000005345
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_230745
Immune System pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_213138
Immune System pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_203140
Axon guidance pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_216714
Innate Immune System pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_019824
OMIM
CCDS CCDS19648
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca