InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arpc3

Summary

InnateDB Protein

IDBP-198171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arpc3

Protein Name

actin related protein 2/3 complex, subunit 3

Synonyms

1110006A04Rik; 21kDa; AA408672; AI788639; p21-Ar; p21Arc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099584

InnateDB Gene

IDBG-198169 (Arpc3)

Protein Structure

UniProt Annotation

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0030833	regulation of actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0070062	extracellular vesicular exosome