InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pak6

Summary

InnateDB Gene

IDBG-198265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pak6

Gene Name

p21 protein (Cdc42/Rac)-activated kinase 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074923

Encoded Proteins

IDBP-198267

p21 protein (Cdc42/Rac)-activated kinase 6

IDBP-259366

p21 protein (Cdc42/Rac)-activated kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137843:
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:118663303-118698020

Strand

Forward strand

Band

Transcripts

ENSMUST00000099557	ENSMUSP00000097153
ENSMUST00000110853	ENSMUSP00000106477
ENSMUST00000152550
ENSMUST00000132843
ENSMUST00000132577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction