InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pak6

Summary

InnateDB Protein

IDBP-259366.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pak6

Protein Name

p21 protein (Cdc42/Rac)-activated kinase 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106477

InnateDB Gene

IDBG-198265 (Pak6)

Protein Structure

UniProt Annotation

Function

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cotranslocates into nucleus with AR in response to androgen induction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2679420

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00786
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00285
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt