InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: C1qa

Summary

InnateDB Gene

IDBG-198277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C1qa

Gene Name

complement component 1, q subcomponent, alpha polypeptide

Synonyms

AI255395; C1q

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036887

Encoded Proteins

IDBP-198279

complement component 1, q subcomponent, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21450789

C1qa :: C1qb :: C1qc (C1q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.

InnateDB Annotation from Orthologs

Summary

PMID 15207504

[Homo sapiens] C1QA is the A-chain of the C1Q recognition subunit of Complement component 1 (C1), and acts a multimolecular protease that triggers the classical pathway of complement and has a major role in the host defence against pathogens.

PMID 20381531

[Homo sapiens] C1Q is involved in the modulation of various immune cells such as dendritic cells, platelets, microglia cells and lymphocytes. C1Q has roles in clearance of apoptotic cells as well as a range of cell processes such as differentiation, chemotaxis, aggregation and adhesion, and pathogenesis of neurodegenerative diseases.

PMID 21450789

[Homo sapiens] C1QA :: C1QB :: C1QC (C1Q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173372:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:136895917-136898803

Strand

Reverse strand

Band

Transcripts

ENSMUST00000046285

ENSMUSP00000048836

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.