Version 5.4
Mus musculus Protein: C1qa
Summary
InnateDB Protein IDBP-198279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1qa
Protein Name complement component 1, q subcomponent, alpha polypeptide
Synonyms AI255395; C1q;
Species Mus musculus
Ensembl Protein ENSMUSP00000048836
InnateDB Gene IDBG-198277 (C1qa)
Protein Structure
UniProt Annotation
Function C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:88223
InterPro IPR001073 Complement C1q protein
IPR008160 Collagen triple helix repeat
IPR008983 Tumour necrosis factor-like domain
PFAM PF00386
PF01391
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P98086
PhosphoSite PhosphoSite-P98086
TrEMBL
UniProt Splice Variant
Entrez Gene 12259
UniGene
RefSeq NP_031598
MGI ID
MGI Symbol C1qa
OMIM
CCDS CCDS18812
HPRD
IMGT
EMBL AK002655 AK136737 AK159210 AL627214 BC002086 CH466552 X58861
GenPept AAH02086 BAB22262 BAE23115 BAE34901 CAA41664 CAM46146 EDL29926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca