Version 5.4
Mus musculus Gene: Med21
Summary
InnateDB Gene IDBG-198395.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Med21
Gene Name mediator complex subunit 21
Synonyms 0610007L03Rik; AI449604; D19234; D6Ertd782e; Srb7; Surb7
Species Mus musculus
Ensembl Gene ENSMUSG00000030291
Encoded Proteins
IDBP-198397
mediator complex subunit 21
IDBP-257680
mediator complex subunit 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152944:
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:146642547-146650602
Strand Forward strand
Band G3
Transcripts
ENSMUST00000032429 ENSMUSP00000032429
ENSMUST00000075077
ENSMUST00000111650 ENSMUSP00000107277
ENSMUST00000125539
ENSMUST00000134387
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0006366 transcription from RNA polymerase II promoter
GO:0019827 stem cell maintenance
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005654 nucleoplasm
GO:0016592 mediator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000152944
View Gene Order
ENSBTAG00000005082
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200794
Mus musculus biological processes pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_025315
OMIM
CCDS CCDS20700
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca