InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med21

Summary

InnateDB Protein

IDBP-198397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med21

Protein Name

mediator complex subunit 21

Synonyms

0610007L03Rik; AI449604; D19234; D6Ertd782e; Srb7; Surb7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032429

InnateDB Gene

IDBG-198395 (Med21)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, skeletal muscles, spleen and testis. {ECO:0000269PubMed:10500093}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0001824	blastocyst development
GO:0006366	transcription from RNA polymerase II promoter
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005654	nucleoplasm
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

MGI:1347064

InterPro

IPR021384 Mediator complex, subunit Med21

PFAM

PF11221

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQ39

PhosphoSite

PhosphoSite-Q9CQ39

TrEMBL

UniProt Splice Variant

Entrez Gene

108098

UniGene

RefSeq

NP_079591

MGI ID

MGI Symbol

Med21

OMIM

CCDS

CCDS20700

HPRD

IMGT

EMBL

AK009742 AK012217 AK014428 AK019417 BC012286

GenPept

AAH12286 BAB26472 BAB28104 BAB29343 BAB31711