InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mst1r

Summary

InnateDB Gene

IDBG-198503.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mst1r

Gene Name

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Synonyms

CD136; CDw136; Fv-2; Fv2; PTK8; Ron; STK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032584

Encoded Proteins

IDBP-198505

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18684919

[Homo sapiens] MST1R regulates endotoxin-induced innate immune responses by regulating the production of and response to IFNG (IFN-gamma).

Entrez Gene

Summary

This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:107906889-107920383

Strand

Forward strand

Band

Transcripts

ENSMUST00000035203

ENSMUSP00000035203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0009615	response to virus
GO:0016032	viral process
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0001725	stress fiber
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164078

View Gene Order

ENSBTAG00000015046

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_1

Alpha6Beta4Integrin pathway

REACTOME

KEGG

INOH

PID NCI

a6b1_a6b4_integrin_pathway

a6b1 and a6b4 Integrin signaling

amb2_neutrophils_pathway

amb2 Integrin signaling

Cross-References

SwissProt

Q62190

TrEMBL

UniProt Splice Variant

Entrez Gene

19882

UniGene

Mm.3901

RefSeq

NM_001287261 NM_009074 XM_006511656 XM_006511658

OMIM

CCDS

CCDS23509

HPRD

IMGT

MGI ID

MGI:99614

MGI Symbol

Mst1r

EMBL

AL731808 U65949 X74736

GenPept

AAC39953 CAA52754

RNA Seq Atlas

19882