Version 5.4
Homo sapiens Gene: MST1R
Summary
InnateDB Gene IDBG-35720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MST1R
Gene Name macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms CD136; CDw136; PTK8; RON
Species Homo sapiens
Ensembl Gene ENSG00000164078
Encoded Proteins
IDBP-35722
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-35724
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-377695
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-377698
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-377699
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-812651
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-812655
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
IDBP-812657
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18684919
MST1R regulates endotoxin-induced innate immune responses by regulating the production of and response to IFNG (IFN-gamma).
Entrez Gene
Summary This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49887002-49903873
Strand Reverse strand
Band p21.31
Transcripts
ENST00000296474 ENSP00000296474
ENST00000344206 ENSP00000341325
ENST00000411578 ENSP00000407926
ENST00000434765 ENSP00000393294
ENST00000440292 ENSP00000414792
ENST00000463789
ENST00000490053
ENST00000467110
ENST00000468525
ENST00000493535
ENST00000485044
ENST00000497001
ENST00000613534 ENSP00000482827
ENST00000612032 ENSP00000481084
ENST00000621387 ENSP00000482642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005011 macrophage colony-stimulating factor receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006928 cellular component movement
GO:0006952 defense response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organismal development
GO:0007338 single fertilization
GO:0008284 positive regulation of cell proliferation
GO:0009615 response to virus
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0038145 macrophage colony-stimulating factor signaling pathway
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0001725 stress fiber
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032584
View Gene Order
ENSBTAG00000015046
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
INOH
PID NCI
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517973
RefSeq NM_001244937 NM_002447 XM_005265170
HUGO
OMIM
CCDS CCDS2807 CCDS58833
HPRD 02545
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca