Mus musculus Gene: Cela3b
Summary
InnateDB Gene IDBG-198563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cela3b
Gene Name chymotrypsin-like elastase family, member 3B
Synonyms 0910001F22Rik; 2310074F01Rik; AI504000; Ela3; Ela3b
Species Mus musculus
Ensembl Gene ENSMUSG00000023433
Encoded Proteins
chymotrypsin-like elastase family, member 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000219073:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:137420999-137430540
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000102522 ENSMUSP00000099581
ENSMUST00000134565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Protein digestion and absorption pathway
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Pancreatic secretion pathway
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q9CQ52
TrEMBL
UniProt Splice Variant
Entrez Gene 67868
UniGene
RefSeq NM_026419
OMIM
CCDS CCDS18817
HPRD
IMGT
MGI ID MGI:1915118
MGI Symbol Cela3b
EMBL AK008858 AK009129 AK010149 AL645468 BC056210 BC061066
GenPept AAH56210 AAH61066 BAB25932 BAB26092 BAB26734 CAM18517
RNA Seq Atlas 67868