Version 5.4
| Homo sapiens Gene: CELA3B | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-281515.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CELA3B | ||||||||
| Gene Name | chymotrypsin-like elastase family, member 3B | ||||||||
| Synonyms | CBPP; E1; EL-1; ELA3B | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000219073 | ||||||||
| Encoded Proteins |
chymotrypsin-like elastase family, member 3B
chymotrypsin-like elastase family, member 3B
chymotrypsin-like elastase family, member 3B
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 1:21977021-21998642 | ||||||||
| Strand | Forward strand | ||||||||
| Band | p36.12 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Pancreatic secretion pathway
Protein digestion and absorption pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Hs.728752 | ||||||||
| RefSeq | NM_007352 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | CCDS219 | ||||||||
| HPRD | 06498 | ||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||