InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itga7

Summary

InnateDB Gene

IDBG-198684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga7

Gene Name

integrin alpha 7

Synonyms

[a]7; alpha7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025348

Encoded Proteins

IDBP-198690

integrin alpha 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135424:
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128933813-128958277

Strand

Forward strand

Band

Transcripts

ENSMUST00000099112

ENSMUSP00000096712

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0043236	laminin binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007519	skeletal muscle tissue development
GO:0016477	cell migration
GO:0048514	blood vessel morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005927	muscle tendon junction
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0031594	neuromuscular junction
GO:0034677	integrin alpha7-beta1 complex
GO:0042383	sarcolemma