Version 5.4
Homo sapiens Gene: ITGA7
Summary
InnateDB Gene IDBG-38762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA7
Gene Name integrin, alpha 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135424
Encoded Proteins
IDBP-38764
integrin, alpha 7
IDBP-38768
integrin, alpha 7
IDBP-377229
integrin, alpha 7
IDBP-584156
integrin, alpha 7
IDBP-591142
integrin, alpha 7
IDBP-600997
integrin, alpha 7
IDBP-591802
integrin, alpha 7
IDBP-600068
integrin, alpha 7
IDBP-595471
integrin, alpha 7
IDBP-594572
integrin, alpha 7
IDBP-592636
integrin, alpha 7
IDBP-585353
integrin, alpha 7
IDBP-587911
integrin, alpha 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55684568-55716043
Strand Reverse strand
Band q13.2
Transcripts
ENST00000257879 ENSP00000257879
ENST00000347027 ENSP00000343009
ENST00000452168 ENSP00000393844
ENST00000553804 ENSP00000452120
ENST00000554327 ENSP00000450693
ENST00000555728 ENSP00000452387
ENST00000557555 ENSP00000451039
ENST00000557058
ENST00000557488
ENST00000556273 ENSP00000450679
ENST00000554543
ENST00000557257 ENSP00000450578
ENST00000553276
ENST00000555687 ENSP00000451311
ENST00000554724 ENSP00000452043
ENST00000553737
ENST00000556371
ENST00000553893 ENSP00000452467
ENST00000555809 ENSP00000450798
ENST00000554359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008360 regulation of cell shape
GO:0016477 cell migration
GO:0030198 extracellular matrix organization
GO:0048514 blood vessel morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005927 muscle tendon junction
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0031594 neuromuscular junction
GO:0034677 integrin alpha7-beta1 complex
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025348
View Gene Order
ENSBTAG00000012897
Not yet available
Pathways
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
REACT_169262
Laminin interactions pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_cs_pathway
Integrin family cell surface interactions
Cross-References
SwissProt
TrEMBL G3V2Q6
UniProt Splice Variant
Entrez Gene 3679
UniGene Hs.524484
RefSeq NM_001144996 NM_001144997 NM_002206 XM_005268839 XM_005268840 XM_005268842 XM_005268844 XM_005268845 XM_005268846 XM_005268847 XM_005268848 XM_005268849 XM_005268850
HUGO HGNC:6143
OMIM 600536
CCDS CCDS44914 CCDS55832 CCDS8888
HPRD 02761
IMGT
EMBL AC009779
GenPept
RNA Seq Atlas 3679

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca