Version 5.4
Homo sapiens Gene: FGF10
Summary
InnateDB Gene IDBG-19873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF10
Gene Name fibroblast growth factor 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070193
Encoded Proteins
IDBP-19875
fibroblast growth factor 10
IDBP-481897
fibroblast growth factor 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:44303544-44389706
Strand Reverse strand
Band p12
Transcripts
ENST00000264664 ENSP00000264664
ENST00000513107 ENSP00000426406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001656 metanephros development
GO:0001759 organ induction
GO:0001823 mesonephros development
GO:0001974 blood vessel remodeling
GO:0003338 metanephros morphogenesis
GO:0006935 chemotaxis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007368 determination of left/right symmetry
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0009880 embryonic pattern specification
GO:0009887 organ morphogenesis
GO:0010468 regulation of gene expression
GO:0010631 epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010838 positive regulation of keratinocyte proliferation
GO:0014070 response to organic cyclic compound
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030324 lung development
GO:0030538 embryonic genitalia morphogenesis
GO:0030855 epithelial cell differentiation
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0031532 actin cytoskeleton reorganization
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032781 positive regulation of ATPase activity
GO:0032808 lacrimal gland development
GO:0032925 regulation of activin receptor signaling pathway
GO:0034394 protein localization to cell surface
GO:0035019 somatic stem cell maintenance
GO:0035108 limb morphogenesis
GO:0035265 organ growth
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042246 tissue regeneration
GO:0042472 inner ear morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042693 muscle cell fate commitment
GO:0043410 positive regulation of MAPK cascade
GO:0043616 keratinocyte proliferation
GO:0045087 innate immune response
GO:0045596 negative regulation of cell differentiation
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046877 regulation of saliva secretion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048286 lung alveolus development
GO:0048514 blood vessel morphogenesis
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048645 organ formation
GO:0048730 epidermis morphogenesis
GO:0048752 semicircular canal morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048807 female genitalia morphogenesis
GO:0048808 male genitalia morphogenesis
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050674 urothelial cell proliferation
GO:0050677 positive regulation of urothelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050872 white fat cell differentiation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051549 positive regulation of keratinocyte migration
GO:0060019 radial glial cell differentiation
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060173 limb development
GO:0060174 limb bud formation
GO:0060425 lung morphogenesis
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060436 bronchiole morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060447 bud outgrowth involved in lung branching
GO:0060449 bud elongation involved in lung branching
GO:0060496 mesenchymal-epithelial cell signaling involved in lung development
GO:0060510 Type II pneumocyte differentiation
GO:0060513 prostatic bud formation
GO:0060541 respiratory system development
GO:0060594 mammary gland specification
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060615 mammary gland bud formation
GO:0060661 submandibular salivary gland formation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060879 semicircular canal fusion
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0061033 secretion by lung epithelial cell involved in lung growth
GO:0061115 lung proximal/distal axis specification
GO:0070075 tear secretion
GO:0070352 positive regulation of white fat cell proliferation
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070384 Harderian gland development
GO:0071157 negative regulation of cell cycle arrest
GO:0071338 positive regulation of hair follicle cell proliferation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000021732
View Gene Order
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_21374
SHC-mediated cascade pathway
REACT_21270
PI-3K cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9416
FGFR2b ligand binding and activation pathway
REACT_9400
FGFR1b ligand binding and activation pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120863
Activated point mutants of FGFR2 pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_13778
Regulation of gene expression in early pancreatic precursor cells pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_13698
Regulation of beta-cell development pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_121155
Signaling by FGFR2 mutants pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_9390
FGFR2 ligand binding and activation pathway
REACT_9396
FGFR ligand binding and activation pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_9483
FGFR1 ligand binding and activation pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt O15520
TrEMBL D6RG33 Q8NFI9
UniProt Splice Variant
Entrez Gene 2255
UniGene
RefSeq NM_004465 XM_005248264
HUGO HGNC:3666
OMIM 602115
CCDS CCDS3950
HPRD
IMGT
EMBL AB002097 AC093289 AC093537 AF411527 AF508782 AY604046 BC069561 BC105021 BC105023 CH471119 CR541665 CR541688 GQ351295 U67918
GenPept AAB61991 AAH69561 AAI05022 AAI05024 AAL05875 AAM46926 AAS99733 ACU00617 BAA22331 CAG46466 CAG46489 EAW56075
RNA Seq Atlas 2255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca