InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF10

Summary

InnateDB Protein

IDBP-19875.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF10

Protein Name

fibroblast growth factor 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264664

InnateDB Gene

IDBG-19873 (FGF10)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269PubMed:16597617}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269PubMed:16501574, ECO:0000269PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005111	type 2 fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0001656	metanephros development
GO:0001759	organ induction
GO:0001823	mesonephros development
GO:0001974	blood vessel remodeling
GO:0003338	metanephros morphogenesis
GO:0006935	chemotaxis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007368	determination of left/right symmetry
GO:0007431	salivary gland development
GO:0007435	salivary gland morphogenesis
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0008589	regulation of smoothened signaling pathway
GO:0009880	embryonic pattern specification
GO:0009887	organ morphogenesis
GO:0010468	regulation of gene expression
GO:0010631	epithelial cell migration
GO:0010634	positive regulation of epithelial cell migration
GO:0010838	positive regulation of keratinocyte proliferation
GO:0014070	response to organic cyclic compound
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030324	lung development
GO:0030538	embryonic genitalia morphogenesis
GO:0030855	epithelial cell differentiation
GO:0030878	thyroid gland development
GO:0030916	otic vesicle formation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016	pancreas development
GO:0031069	hair follicle morphogenesis
GO:0031076	embryonic camera-type eye development
GO:0031532	actin cytoskeleton reorganization
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032781	positive regulation of ATPase activity
GO:0032808	lacrimal gland development
GO:0032925	regulation of activin receptor signaling pathway
GO:0034394	protein localization to cell surface
GO:0035019	somatic stem cell maintenance
GO:0035108	limb morphogenesis
GO:0035265	organ growth
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042060	wound healing
GO:0042246	tissue regeneration
GO:0042472	inner ear morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042693	muscle cell fate commitment
GO:0043410	positive regulation of MAPK cascade
GO:0043616	keratinocyte proliferation
GO:0045087	innate immune response
GO:0045596	negative regulation of cell differentiation
GO:0045739	positive regulation of DNA repair
GO:0045740	positive regulation of DNA replication
GO:0045747	positive regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046877	regulation of saliva secretion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0048286	lung alveolus development
GO:0048514	blood vessel morphogenesis
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048565	digestive tract development
GO:0048566	embryonic digestive tract development
GO:0048645	organ formation
GO:0048730	epidermis morphogenesis
GO:0048752	semicircular canal morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048807	female genitalia morphogenesis
GO:0048808	male genitalia morphogenesis
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050673	epithelial cell proliferation
GO:0050674	urothelial cell proliferation
GO:0050677	positive regulation of urothelial cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050872	white fat cell differentiation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051145	smooth muscle cell differentiation
GO:0051549	positive regulation of keratinocyte migration
GO:0060019	radial glial cell differentiation
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060173	limb development
GO:0060174	limb bud formation
GO:0060425	lung morphogenesis
GO:0060428	lung epithelium development
GO:0060430	lung saccule development
GO:0060436	bronchiole morphogenesis
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060447	bud outgrowth involved in lung branching
GO:0060449	bud elongation involved in lung branching
GO:0060496	mesenchymal-epithelial cell signaling involved in lung development
GO:0060510	Type II pneumocyte differentiation
GO:0060513	prostatic bud formation
GO:0060541	respiratory system development
GO:0060594	mammary gland specification
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060615	mammary gland bud formation
GO:0060661	submandibular salivary gland formation
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060667	branch elongation involved in salivary gland morphogenesis
GO:0060879	semicircular canal fusion
GO:0060915	mesenchymal cell differentiation involved in lung development
GO:0061033	secretion by lung epithelial cell involved in lung growth
GO:0061115	lung proximal/distal axis specification
GO:0070075	tear secretion
GO:0070352	positive regulation of white fat cell proliferation
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070384	Harderian gland development
GO:0071157	negative regulation of cell cycle arrest
GO:0071338	positive regulation of hair follicle cell proliferation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix