InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fanca

Summary

InnateDB Gene

IDBG-198733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fanca

Gene Name

Fanconi anemia, complementation group A

Synonyms

AW208693; FACA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032815

Encoded Proteins

IDBP-198735

Fanconi anemia, complementation group A

IDBP-400351

Fanconi anemia, complementation group A

IDBP-538915

Fanconi anemia, complementation group A

IDBP-533391

Fanconi anemia, complementation group A

IDBP-536824

Fanconi anemia, complementation group A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187741:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123268300-123318576

Strand

Reverse strand

Band

Transcripts

ENSMUST00000035495	ENSMUSP00000045217
ENSMUST00000118395	ENSMUSP00000113125
ENSMUST00000135702
ENSMUST00000126834	ENSMUSP00000116732
ENSMUST00000155510	ENSMUSP00000118712
ENSMUST00000155279
ENSMUST00000146687
ENSMUST00000155488
ENSMUST00000127904	ENSMUSP00000116614
ENSMUST00000133950
ENSMUST00000150318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0007140	male meiosis
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0043240	Fanconi anaemia nuclear complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000187741

View Gene Order

ENSBTAG00000001906

Not yet available

Pathways

NETPATH

REACTOME

REACT_233397

DNA Repair pathway

REACT_232842

Fanconi Anemia pathway pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18410

Fanconi Anemia pathway pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.6536

RefSeq

NM_016925 XM_006530661 XM_006530663 XM_006530664 XM_006530665 XM_006530666

OMIM

CCDS

CCDS22753

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas