InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fanca

Summary

InnateDB Protein

IDBP-198735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fanca

Protein Name

Fanconi anemia, complementation group A

Synonyms

AW208693; FACA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045217

InnateDB Gene

IDBG-198733 (Fanca)

Protein Structure

UniProt Annotation

Function

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=The major form is nuclear. The minor form is cytoplasmic.

Disease Associations

Tissue Specificity

Mainly expressed in testis and lymphoid tissues like thymus, lymph nodes, and spleen, and at lower levels in kidney and ovary. {ECO:0000269PubMed:10754110}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0007140	male meiosis
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0042127	regulation of cell proliferation