Version 5.4
Mus musculus Gene: Nmnat2
Summary
InnateDB Gene IDBG-198773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nmnat2
Gene Name nicotinamide nucleotide adenylyltransferase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042751
Encoded Proteins
IDBP-198775
nicotinamide nucleotide adenylyltransferase 2
IDBP-787989
nicotinamide nucleotide adenylyltransferase 2
IDBP-787990
nicotinamide nucleotide adenylyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157064:
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:152954993-153119261
Strand Forward strand
Band G3
Transcripts
ENSMUST00000043313 ENSMUSP00000041110
ENSMUST00000186368 ENSMUSP00000140585
ENSMUST00000186621 ENSMUSP00000140497
ENSMUST00000185241
ENSMUST00000187569
ENSMUST00000190960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity
GO:0003824 catalytic activity
GO:0004515 nicotinate-nucleotide adenylyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0009058 biosynthetic process
GO:0009435 NAD biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157064
View Gene Order
ENSBTAG00000000795
Not yet available
Pathways
NETPATH
REACTOME
REACT_189088
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_189085
Disease pathway
REACT_188937
Metabolism pathway
REACT_189089
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_189086
Defective GIF causes intrinsic factor deficiency pathway
REACT_189075
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_189076
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_189078
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_189098
Defective CD320 causes methylmalonic aciduria pathway
REACT_189097
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_189096
Defects in biotin (Btn) metabolism pathway
REACT_189095
Defective BTD causes biotidinase deficiency pathway
REACT_189093
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_189092
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_189091
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_189090
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_254651
Metabolism of vitamins and cofactors pathway
REACT_238663
Metabolism of water-soluble vitamins and cofactors pathway
REACT_209575
Nicotinate metabolism pathway
REACT_189110
Defects in vitamin and cofactor metabolism pathway
REACT_189116
Defects in cobalamin (B12) metabolism pathway
REACT_189114
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_189100
Defective HLCS causes multiple carboxylase deficiency pathway
KEGG
mmu00760
Nicotinate and nicotinamide metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11088
Nicotinate metabolism pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
REACT_208874
Defective GIF causes intrinsic factor deficiency pathway
REACT_223924
Defects in cobalamin (B12) metabolism pathway
REACT_223300
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_218264
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_205789
Nicotinate metabolism pathway
REACT_227887
Defects in vitamin and cofactor metabolism pathway
REACT_217107
Defects in biotin (Btn) metabolism pathway
REACT_202103
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_210590
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_224094
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_221779
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_210941
Defective BTD causes biotidinase deficiency pathway
REACT_222920
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_216256
Defective CD320 causes methylmalonic aciduria pathway
REACT_218209
Metabolism of water-soluble vitamins and cofactors pathway
REACT_209855
Metabolism of vitamins and cofactors pathway
REACT_212778
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_219139
Metabolism pathway
REACT_225745
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_223191
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_207087
Disease pathway
REACT_212600
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_221291
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
KEGG
hsa00760
Nicotinate and nicotinamide metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_175460 XM_006529455
OMIM
CCDS CCDS15368
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca