InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nmnat2

Summary

InnateDB Protein

IDBP-198775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nmnat2

Protein Name

nicotinamide nucleotide adenylyltransferase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041110

InnateDB Gene

IDBG-198773 (Nmnat2)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity
GO:0003824	catalytic activity
GO:0004515	nicotinate-nucleotide adenylyltransferase activity
GO:0005524	ATP binding