InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Casc5

Summary

InnateDB Gene

IDBG-198797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casc5

Gene Name

cancer susceptibility candidate 5

Synonyms

2310043D08Rik; 5730505K17Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027326

Encoded Proteins

IDBP-198799

cancer susceptibility candidate 5

IDBP-198801

cancer susceptibility candidate 5

IDBP-198803

cancer susceptibility candidate 5

IDBP-532411

cancer susceptibility candidate 5

IDBP-536377

cancer susceptibility candidate 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137812:
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:119047119-119105501

Strand

Forward strand

Band

Transcripts

ENSMUST00000028799	ENSMUSP00000028799
ENSMUST00000099542	ENSMUSP00000097140
ENSMUST00000028802	ENSMUSP00000028802
ENSMUST00000152380	ENSMUSP00000118646
ENSMUST00000153300	ENSMUSP00000120905

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0010923	negative regulation of phosphatase activity
GO:0034501	protein localization to kinetochore
GO:0071173	spindle assembly checkpoint