InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casc5

Summary

InnateDB Protein

IDBP-198799.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casc5

Protein Name

cancer susceptibility candidate 5

Synonyms

2310043D08Rik; 5730505K17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028799

InnateDB Gene

IDBG-198797 (Casc5)

Protein Structure

UniProt Annotation

Function

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0010923	negative regulation of phosphatase activity
GO:0034501	protein localization to kinetochore
GO:0071173	spindle assembly checkpoint