Version 5.4
Mus musculus Gene: Lpar3
Summary
InnateDB Gene IDBG-199063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpar3
Gene Name lysophosphatidic acid receptor 3
Synonyms Edg7; lpA3
Species Mus musculus
Ensembl Gene ENSMUSG00000036832
Encoded Proteins
IDBP-199065
lysophosphatidic acid receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171517:
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:146220961-146286214
Strand Forward strand
Band H2
Transcripts
ENSMUST00000039164 ENSMUSP00000037712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004930 G-protein coupled receptor activity
GO:0005543 phospholipid binding
GO:0070915 lysophosphatidic acid receptor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032060 bleb assembly
GO:0043410 positive regulation of MAPK cascade
GO:0048672 positive regulation of collateral sprouting
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928 positive regulation of calcium ion transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171517
View Gene Order
ENSBTAG00000003791
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_232027
Lysosphingolipid and LPA receptors pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_18365
Lysosphingolipid and LPA receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
Cross-References
SwissProt Q9EQ31
TrEMBL Q544B4
UniProt Splice Variant
Entrez Gene 65086
UniGene Mm.155520
RefSeq NM_022983
OMIM
CCDS CCDS17901
HPRD
IMGT
MGI ID MGI:1929469
MGI Symbol Lpar3
EMBL AF272364 AF272365 AF293845 AK042084 BC125460 BC125462 CH466532
GenPept AAG13674 AAI25461 AAI25463 AAK02017 BAC31159 EDL11980
RNA Seq Atlas 65086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca