InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpar3

Summary

InnateDB Protein

IDBP-199065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpar3

Protein Name

lysophosphatidic acid receptor 3

Synonyms

Edg7; lpA3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037712

InnateDB Gene

IDBG-199063 (Lpar3)

Protein Structure

UniProt Annotation

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005543	phospholipid binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032060	bleb assembly
GO:0043410	positive regulation of MAPK cascade
GO:0048672	positive regulation of collateral sprouting
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928	positive regulation of calcium ion transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1929469

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR002277 Lysophosphatidic acid receptor EDG-2
IPR004065 Lysophosphatidic acid receptor
IPR005385 Lysophosphatidic acid receptor EDG-7
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00534
PR01148
PR01527
PR01560

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EQ31