Version 5.4
Mus musculus Gene: Spint1
Summary
InnateDB Gene IDBG-199130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spint1
Gene Name serine protease inhibitor, Kunitz type 1
Synonyms HAI-1
Species Mus musculus
Ensembl Gene ENSMUSG00000027315
Encoded Proteins
IDBP-199132
serine protease inhibitor, Kunitz type 1
IDBP-259441
serine protease inhibitor, Kunitz type 1
IDBP-259443
serine protease inhibitor, Kunitz type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166145:
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119237362-119249527
Strand Forward strand
Band E5
Transcripts
ENSMUST00000028783 ENSMUSP00000028783
ENSMUST00000110817 ENSMUSP00000106441
ENSMUST00000110816 ENSMUSP00000106440
ENSMUST00000139903
ENSMUST00000134872
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0001892 embryonic placenta development
GO:0010951 negative regulation of endopeptidase activity
GO:0030198 extracellular matrix organization
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060674 placenta blood vessel development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166145
View Gene Order
ENSBTAG00000004086
Not yet available
Cross-References
SwissProt Q9R097
TrEMBL
UniProt Splice Variant
Entrez Gene 20732
UniGene Mm.104955 Mm.406075
RefSeq NM_016907 XM_006499062
OMIM
CCDS CCDS16597
HPRD
IMGT
MGI ID MGI:1338033
MGI Symbol Spint1
EMBL AF099018 AL929318 BC005769 CH466519
GenPept AAF02490 AAH05769 CAM25337 EDL27946
RNA Seq Atlas 20732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca